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HCLS1
HCLS1 (Hematopoietic Cell-Specific Lyn Substrate 1) is a Protein Coding gene. Diseases associated with HCLS1 include Spherocytosis, Type 1 and Congenital Hemolytic Anemia. Among its related pathways are Development Slit-Robo signaling and Immune response Fc epsilon RI pathway. Gene Ontology (GO) annotations related to this gene include protein kinase binding and protein complex binding. An important paralog of this gene is CTTN.
Protein class
Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Kupffer cells, Macrophages, monocytes, NK-cells, T-cells, B-cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (Daudi, HMC-1, RPMI-8226, THP-1, U-266/70, U-698)
Interaction
Associates with the SH2 and SH3 domains of LCK. Binding to he LCK SH3 domain occurs constitutively, while binding to the LCK SH2 domain occurs only upon TCR stimulation. A similar binding pattern was observed with LYN, but not with FYN in which the FYN SH2 region associates upon TCR stimulation but the FYN SH3 region does not associate regardless of TCR stimulation. Directly associates with HAX1, through binding to its C-terminal region. Interacts with HS1BP3. Interacts with FES/FPS (By similarity). Interacts (via SH2 domain) with FGR. Forms a multiprotein complex with LYN and ANKRD54 (By similarity).
More Types Infomation
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: ELISA, WB
- Recombinant Mouse Anti-HCLS1 Antibody (VS-0923-FY83) (VS-0923-FY83)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB
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For Research Use Only. Not For Clinical Use.