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HCRT
This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors HCRTR1 and HCRTR2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis.
Protein class
Disease related genes, Human disease related genes
Predicted location
Secreted
Single cell type specificity
Cell type enhanced (Enteroendocrine cells, Oligodendrocyte precursor cells, Collecting duct cells, Kupffer cells, Proximal enterocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Not detected
Molecular function
Neuropeptide
More Types Infomation
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- Class: Class II
- Antigen: HCRT
- Antigen Species: Human
- Peptide: MNLPSTKVSWAAV
- Conjugate: PE
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, ELISA, IF, IHC, IP
-
- Species Reactivity: Human
- Application: IHC-Fr
- Recombinant Human Anti-HCRT Soluble TCR (CBY8) (KIH) (VS-0622-YF6106)
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- Species Reactivity: Human
- Epitope: HGAGNHAAGILTL + AMID(L66)
- MHC: HLA-DQA1*01:02/DQB1*06:02
- Recombinant Human Anti-HCRT Soluble TCR (CBY7) (KIH) (VS-0622-YF6105)
-
- Species Reactivity: Human
- Epitope: ASGNHAAGILTM + AMID(M97)
- MHC: HLA-DQA1*01:02/DQB1*06:02
- Recombinant Human Anti-HCRT Soluble TCR (CBY8) (C-Cys) (VS-0622-YF3398)
-
- Species Reactivity: Human
- Epitope: HGAGNHAAGILTL + AMID(L66)
- MHC: HLA-DQA1*01:02/DQB1*06:02
- Recombinant Human Anti-HCRT Soluble TCR (CBY7) (C-Cys) (VS-0622-YF3397)
-
- Species Reactivity: Human
- Epitope: ASGNHAAGILTM + AMID(M97)
- MHC: HLA-DQA1*01:02/DQB1*06:02
- Human Anti-HCRT Recombinant Soluble TCR (clone CBY8) (scTCR-234YF-S(P))
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- Species Reactivity: Human
- Epitope: HGAGNHAAGILTL + AMID(L66)
- MHC: HLA-DQA1*01:02/DQB1*06:02
- Human Anti-HCRT Recombinant Soluble TCR (clone CBY7) (scTCR-233YF-S(P))
-
- Species Reactivity: Human
- Epitope: ASGNHAAGILTM + AMID(M97)
- MHC: HLA-DQA1*01:02/DQB1*06:02
- Recombinant Human Anti-HCRT Soluble TCR (CBY8) (ZIP-Fos/ZIP-Jun) (VS-0622-YF690)
-
- Species Reactivity: Human
- Epitope: HGAGNHAAGILTL + AMID(L66)
- MHC: HLA-DQA1*01:02/DQB1*06:02
- Recombinant Human Anti-HCRT Soluble TCR (CBY7) (ZIP-Fos/ZIP-Jun) (VS-0622-YF689)
-
- Species Reactivity: Human
- Epitope: ASGNHAAGILTM + AMID(M97)
- MHC: HLA-DQA1*01:02/DQB1*06:02
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For Research Use Only. Not For Clinical Use.