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HLTF
This gene encodes a member of the SWI/SNF family. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein contains a RING finger DNA binding motif. Two transcript variants encoding the same protein have been found for this gene. However, use of an alternative translation start site produces an isoform that is truncated at the N-terminus compared to the full-length protein. [provided by RefSeq, Jul 2008]
Protein class
Enzymes, Metabolic proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Spermatocytes, Spermatogonia)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Interacts with SP1 and SP3 independently of DNA; the interaction with these transcriptional factors may be required for basal transcription of target genes. Interacts with EGR1; the interaction requires prior binding to DNA and represses c-Rel via a DNA looping mechanism (By similarity). Interacts with GATA4 (By similarity). Interacts with PCNA; the interaction promotes polyubiquitination of PCNA through association with the UBE2B-RAD18 and UBE2V2-UBE2N ubiquitin ligase complexes. Interacts with RAD18, SHPRH, UBE2V2 and UBE2N.
Molecular function
Activator, Chromatin regulator, DNA-binding, Helicase, Hydrolase, Multifunctional enzyme, Transferase
More Types Infomation
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- Derivation: Phage display library
- Species Reactivity: Rat, Human
- Type: Rabbit IgG
- Application: WB, IHC-P, ICC, IF
- Mouse Anti-HLTF Recombinant Antibody (clone HLTF8F1) (HPAB-0024-LS)
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized IgG1, κ
- Application: ELISA, WB, IP, IF
- Mouse Anti-HLTF Recombinant Antibody (clone HLTF8F1); Fab Fragment (HPAB-0024-LS-F(E))
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA, WB, IP, IF
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, ICC, IF
- Mouse Anti-HLTF Recombinant Antibody (clone HLTF8F1); scFv Fragment (HPAB-0024-LS-S(P))
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized scFv
- Application: ELISA, WB, IP, IF
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For Research Use Only. Not For Clinical Use.