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HOOK2
Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Proximal enterocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (MCF7, RT4)
Interaction
Self-associates (PubMed:18799622). Component of the FTS/Hook/FHIP complex (FHF complex), composed of AKTIP/FTS, FHIP1B, and one or more members of the Hook family of proteins HOOK1, HOOK2, and HOOK3 (PubMed:18799622). May interact directly with AKTIP/FTS, HOOK1 and HOOK3 (PubMed:18799622, PubMed:32073997). Associates with several subunits of the homotypic vesicular sorting complex (the HOPS complex) including VPS16 and VPS41; these interactions may be indirect (PubMed:18799622). Interacts with CNTRL (PubMed:17140400). Interacts with microtubules (PubMed:11238449). Interacts with ZC3H14 (PubMed:19273536). Interacts with LRGUK (via guanylate kinase-like domain) (By similarity). Interacts with CCDC181 (By similarity). Interacts with AP4M1; the interaction is direct, mediates the interaction between FTS-Hook-FHIP (FHF) complex and AP-4 and the perinuclear distribution of AP-4 (PubMed:32073997).
More Types Infomation
- Recombinant Mouse Anti-Human HOOK2 Antibody (MOB-2381MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: WB
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC, FC
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For Research Use Only. Not For Clinical Use.