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HRAS
This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene. [provided by RefSeq, Jul 2008]
Protein class
Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, RAS pathway related proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Suprabasal keratinocytes)
Immune cell specificity
Immune cell enhanced (non-classical monocyte)
Cell line specificity
Low cell line specificity
Interaction
In its GTP-bound form interacts with PLCE1 (PubMed:11022048). Interacts with TBC1D10C (PubMed:17230191). Interacts with RGL3 (By similarity). Interacts with HSPD1 (By similarity). Found in a complex with at least BRAF, HRAS, MAP2K1, MAPK3 and RGS14 (By similarity). Interacts (active GTP-bound form) with RGS14 (via RBD 1 domain) (By similarity). Forms a signaling complex with RASGRP1 and DGKZ (PubMed:11257115). Interacts with RASSF5 (PubMed:18596699). Interacts with PDE6D (PubMed:11980706). Interacts with IKZF3 (PubMed:10369681). Interacts with RACK1 (PubMed:14500341). Interacts with PIK3CG; the interaction is required for membrane recruitment and beta-gamma G protein dimer-dependent activation of the PI3K gamma complex PIK3CG:PIK3R6 (By similarity). Interacts with RAPGEF2 (PubMed:10608844, PubMed:11598133).
Molecular function
Hydrolase
More Types Infomation
Related Diseases
Bladder Cancer
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- Species Reactivity: Human
- Application: WB, ELISA
-
- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IP
-
- Species Reactivity: Human
- Type: Human Fab
- Application: WB, IHC, IF, FuncS
- Human Anti-HRAS Antibody (clone YC106), mRNA (PABZ-074-mRNA)
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- Species Reactivity: Human
-
- Species Reactivity: Human
- Type: Human scFv
- Application: WB, IHC, IF, FuncS
- Human Anti-HRAS Recombinant Antibody (clone Y13-238) (FAMAB-1496CQ)
-
- Species Reactivity: Human, Mouse
- Type: Human IgG1
- Application: IP
-
- Species Reactivity: Human
- Type: Human IgG
- Application: WB, IHC, IF, FuncS
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IF, IHC
- Human Anti-HRAS Antibody (clone Y13-238), mRNA (FAMAB-1496CQ-mRNA)
-
- Species Reactivity: Human, Mouse
- Rat Anti-HRAS Recombinant Antibody (clone CBL947) (NEUT-914CQ)
-
- Species Reactivity: Human, Mouse, Rat
- Type: Rat IgG1, κ
- Application: IF, IHC, IP, Neut, WB
- Rat Anti-HRAS Recombinant Antibody (clone Y13-259) (NEUT-913CQ)
-
- Species Reactivity: Human, Mouse, Rat
- Type: Rat IgG1, κ
- Application: WB, ICC, IF, IP, IHC-P, Neut, IHC-Fr
- Chicken Anti-H-Ras Polyclonal IgY (BRD-1076MZ)
-
- Species Reactivity: Rat, Mouse
- Type: Chicken antibody
- Application: WB
- Mouse Anti-HRAS Recombinant Antibody (clone CBH03YJ); scFv Fragment (HPAB-0159-YJ-S(P))
-
- Derivation: scFv Phage display library
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, ICC, FuncS
- Mouse Anti-HRAS Recombinant Antibody (clone CBH03YJ); Fab Fragment (HPAB-0159-YJ-F(E))
-
- Derivation: scFv Phage display library
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, ICC, FuncS
- Mouse Anti-HRAS Recombinant Antibody (clone CBH03YJ) (HPAB-0159-YJ)
-
- Derivation: scFv Phage display library
- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA, ICC, FuncS
- Chicken Anti-HRAS Polyclonal IgY (BRD-0260MZ)
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- Species Reactivity: Mouse, Rat
- Type: Chicken antibody
- Application: WB
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