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HSF4
Heat-shock transcription factors (HSFs) activate heat-shock response genes under conditions of heat or other stresses. HSF4 lacks the carboxyl-terminal hydrophobic repeat which is shared among all vertebrate HSFs and has been suggested to be involved in the negative regulation of DNA binding activity. Two alternatively spliced transcripts encoding distinct isoforms and possessing different transcriptional activity have been described. [provided by RefSeq, Jul 2008]
Protein class
Disease related genes, Human disease related genes, Plasma proteins, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Horizontal cells, Astrocytes, Leydig cells, Excitatory neurons, Inhibitory neurons)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (hTERT-RPE1, T-47d, U-266/70)
Interaction
Homotrimer (By similarity). Exhibits constitutive DNA binding and forms trimers even in the absence of stress (By similarity). Interacts with ALKBH4, DUSP26, MAPK1, MAPK2, MAPK8 and MAP kinase p38 (PubMed:16581800, PubMed:23145062).
Molecular function
Activator, DNA-binding, Repressor
More Types Infomation
- Recombinant Mouse Anti-Human HSF4 Antibody (MOB-1136MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: WB
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ICC, IHC-P, WB
- Mouse Anti-HSF4 Recombinant Antibody (clone 2E7) (VS3-QX544)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IHC, ICC, FC, ELISA
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For Research Use Only. Not For Clinical Use.