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IGHD
Predicted to enable antigen binding activity and immunoglobulin receptor binding activity. Involved in positive regulation of interleukin-1 production. Located in blood microparticle and extracellular exosome.
Protein class
Immunoglobulin genes
Predicted location
Intracellular, Membrane, Secreted (different isoforms)
Single cell type specificity
Group enriched (Plasma cells, T-cells, B-cells)
Immune cell specificity
Group enriched (naive B-cell, memory B-cell)
Cell line specificity
Group enriched (Daudi, U-698)
Interaction
Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked (PubMed:20176268). An IgD molecule contains thus a delta heavy chain combined with either a kappa or a lambda light chains. Kappa light chains are found predominantly on the membrane IgD (mIgD) form and lambda on the secreted IgD (sIgD) form, this fact is poorly understood. Membrane-bound IgD molecules are non-covalently associated with a heterodimer of CD79A and CD79B (PubMed:11282392).
More Types Infomation
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC
- Mouse Anti-IGHD Antibody (clone IgD26), mRNA (FAMAB-1160CQ-mRNA)
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- Species Reactivity: Human
- Mouse Anti-IGHD Recombinant Antibody (clone IgD26) (FAMAB-1160CQ)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: FACS, WB, IHC
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- Species Reactivity: Mouse
- Type: Mouse IgG2a, κ
- Application: FuncS
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- Species Reactivity: Human
- Type: Mouse IgM
- Application: WB
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For Research Use Only. Not For Clinical Use.