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IGSF5
Provides, together with MAGI1, an adhesion machinery at tight junctions, which may regulate the permeability of kidney glomerulus and small intestinal epithelial cells. Mediates calcium-independent homophilic cell adhesion. In testis, it may function as a cell adhesion molecule rather than a tight-junction protein. It may participate in the adhesion between spermatogonia-spermatogonia, spermatogonia-Sertoli cells, and Sertoli cells-Sertoli cells (By similarity).
Predicted location
Membrane
Single cell type specificity
Cell type enriched (Syncytiotrophoblasts)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (T-47d)
Interaction
Interacts with MAGI1 at tight junctions, forms a tripartite complex with NPHS1. Interacts with LNX1 isoform 2 via its PDZ 2 domain, it may also interact with other isoforms containing this domain.
More Types Infomation
- Recombinant Anti-Human IGSF5 Antibody (MOB-1528z)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: IgG
- Application: ELISA, WB, Neut, FuncS
- Recombinant Anti-Human IGSF5 Antibody scFv Fragment (MOB-1528z-S(P))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: ELISA, WB, FuncS
- Recombinant Anti-Human IGSF5 Antibody Fab Fragment (MOB-1528z-F(E))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: FC, Neut, Funcs
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For Research Use Only. Not For Clinical Use.