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IQGAP1
This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines.
Protein class
Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Interacts with CDC42; the interaction is demonstrated with IQGAP1 in GTP-bound and in nucleotide-free state (PubMed:15355962). Interacts with RAC1 (PubMed:15355962). Does not interact with RHOA. Interacts with TSG101 (PubMed:17853893). Interacts with PAK6 (PubMed:18642328). Interacts with TMEM14B; this interaction increases IQGAP1 phosphorylation and induces its nuclear translocation (PubMed:29033352). Interacts with SASH1 (PubMed:23333244). Interacts with PJVK (By similarity). (Microbial infection) Interacts with ebolavirus vp40. (Microbial infection) Interacts with human cytomegalovirus protein UL5.
Molecular function
Calmodulin-binding
More Types Infomation
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- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
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- Species Reactivity: Human
- Application: ICC/IF, IHC-P, WB
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: ICC, IHC-P, WB
-
- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, IHC-P, ICC, IF, FC
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- Derivation: Rabbit
- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, ELISA
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For Research Use Only. Not For Clinical Use.