Loading...
IRS1
This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance.
Protein class
Disease related genes, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Theca cells, Granulosa cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Low cell line specificity
Interaction
Interacts with UBTF and PIK3CA (By similarity). Interacts (via phosphorylated YXXM motifs) with PIK3R1 (By similarity). Interacts with ROCK1 and FER (By similarity). Interacts (via PH domain) with PHIP (By similarity). Interacts with GRB2 (By similarity). Interacts with SOCS7 (PubMed:16127460). Interacts (via IRS-type PTB domain) with IGF1R and INSR (via the tyrosine-phosphorylated NPXY motif) (PubMed:7541045, PubMed:7559478, PubMed:7537849). Interacts with ALK (PubMed:15226403, PubMed:16878150). Interacts with EIF2AK2/PKR (By similarity). Interacts with GKAP1 (By similarity). Interacts with DGKZ in the absence of insulin; insulin stimulation decreases this interaction (By similarity). Found in a ternary complex with DGKZ and PIP5K1A in the absence of insulin stimulation (By similarity).
Molecular function
Transducer
More Types Infomation
Related Signaling Pathways
Insulin Signaling Pathway
mTOR Signaling Pathway
PI3K-Akt Signaling Pathway
PPAR Signaling Pathway
Related Diseases
Insulin Resistance
- PE-A*02:01/Human IRS1 (GLENGLNYI) MHC Tetramer (MHC-LC4426)
-
- Class: Class I
- Antigen: IRS1
- Antigen Species: Human
- Peptide: GLENGLNYI
- Conjugate: PE
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: WB, FC, IHC
- Recombinant Mouse Anti-IRS1 Antibody (CBL216) (NEUT-1540CQ)
-
- Species Reactivity: Human, Bovine, Porcine, Sheep
- Type: IgG1
- Application: Inhib
- Mouse Anti-IRS1 Recombinant Antibody (clone IRS 8-63) (FAMAB-1375CQ)
-
- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG1
- Application: IB, IP, WB
-
- Species Reactivity: Human
- Type: IgG
- Application: WB, IHC-P
- Rabbit Anti-IRS1 Recombinant Antibody (clone AFY0016) (MOR-0045-FY)
-
- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: IHC, WB, Inhib
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IF, IHC
- Mouse Anti-IRS1 Antibody (clone IRS 8-63), mRNA (FAMAB-1375CQ-mRNA)
-
- Species Reactivity: Human, Mouse, Rat
-
- Species Reactivity: Human
- Type: IgG
- Application: WB, IF, ICC, FC
-
- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, ICC, IF, IHC
Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us
Can't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag
For Research Use Only. Not For Clinical Use.