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KCNAB1
KCNAB1 (Potassium Voltage-Gated Channel Subfamily A Regulatory Beta Subunit 1) is a Protein Coding gene. Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Diseases associated with KCNAB1 include Episodic Ataxia, Type 1 and Episodic Ataxia.
Protein class
Transporters
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Inhibitory neurons, Oligodendrocyte precursor cells, Excitatory neurons, Oligodendrocytes, Bipolar cells, Sertoli cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (HEL, hTEC/SVTERT24-B)
Interaction
Homotetramer (By similarity). Interaction with tetrameric potassium channel alpha subunits gives rise to a heterooctamer (Probable). Identified in potassium channel complexes containing KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNAB1 and KCNAB2 (By similarity). Interacts with KCNA1 (By similarity). Interacts with the dimer formed by GNB1 and GNG2; this enhances KCNA1 binding (By similarity). Interacts with KCNA4 (PubMed:9763623). Interacts with KCNA5 (PubMed:12130714). Interacts with KCNB2 (By similarity). Interacts with SQSTM1 (By similarity). Part of a complex containing KCNA1, KCNA4 and LGI1; interaction with LGI1 inhibits down-regulation of KCNA1 channel activity (By similarity).
Molecular function
Ion channel, Oxidoreductase, Voltage-gated channel
More Types Infomation
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- Species Reactivity: Human
- Application: ICC/IF, IHC-P, IHC-Fr, WB
- Rabbit Anti-KCNAB1 Recombinant Antibody (VS-0522-LC210) (VS-0522-LC210)
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- Species Reactivity: Rat, Human, Mouse
- Type: Rabbit IgG
- Application: WB, IF, IHC
- Human Anti-KCNAB1 Recombinant Antibody (VS-0522-LC209) (VS-0522-LC209)
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- Species Reactivity: Rat, Human, Mouse
- Type: Human IgG1
- Application: WB, IF, IHC
- Rat Anti-KCNAB1 Recombinant Antibody (VS-0522-LC208) (VS-0522-LC208)
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- Species Reactivity: Rat, Human, Mouse
- Type: Rat IgG2b
- Application: WB, IF, IHC
- Mouse Anti-KCNAB1 Recombinant Antibody (VS-0522-LC207) (VS-0522-LC207)
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- Species Reactivity: Rat, Human, Mouse
- Type: Mouse IgG2a
- Application: WB, IF, IHC
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For Research Use Only. Not For Clinical Use.