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KCNIP1
This gene encodes a member of the family of cytosolic voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the neuronal calcium sensor (NCS) family of the calcium binding EF-hand proteins. They associate with Kv4 alpha subunits to form native Kv4 channel complexes. The encoded protein may regulate rapidly inactivating (A-type) currents, and hence neuronal membrane excitability, in response to changes in the concentration of intracellular calcium. Alternative splicing results in multiple transcript variants encoding different isoforms.
Protein class
Transporters
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Inhibitory neurons, Oligodendrocyte precursor cells, Microglial cells, Astrocytes, Horizontal cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enriched (RPTEC TERT1)
Interaction
Component of heteromultimeric potassium channels. Identified in potassium channel complexes containing KCND1, KCND2, KCND3, KCNIP1, KCNIP2, KCNIP3, KCNIP4, DPP6 and DPP10 (By similarity). Part of a heterooctamer composed of the tetrameric channel and four KCNIP1 chains. Interacts with KCND3 and the N-terminal domain of KCND2. Probably part of a complex consisting of KCNIP1, KCNIP2 isoform 3 and KCND2. Self-associates to form homodimers and homotetramers. Interacts with KCNIP2 isoform 3 in a calcium-dependent manner. Interacts with Naja atra venom CTX3.
Molecular function
Ion channel, Potassium channel, Voltage-gated channel
More Types Infomation
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, IP, FC
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- Species Reactivity: Human
- Application: ICC/IF, IP, IHC-P, IHC-Fr
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For Research Use Only. Not For Clinical Use.