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KDM6A
KDM6A is an 154 kDa ubiquitously transcribed X chromosome tetraticopeptide repeat protein that is predicted to interact with TLE1. KDM6A contains a jumonji C domain and specifically demethylates di and tri methyl histone H3 at K27.
Protein class
Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Potential drug targets
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Oligodendrocytes, Oligodendrocyte precursor cells, Microglial cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Interacts with TLE1 (By similarity). Component of the MLL2/3 complex (also named ASCOM complex), at least composed of KMT2D/MLL2 or KMT2C/MLL3, ASH2L, RBBP5, WDR5, NCOA6, DPY30, KDM6A (or KDM6B), PAXIP1/PTIP, PAGR1 and alpha- and beta-tubulin (PubMed:17500065, PubMed:17713478). Interacts with SUPT6H. Interacts with SMARCA4 (By similarity).
Molecular function
Chromatin regulator, Dioxygenase, Oxidoreductase
More Types Infomation
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- Species Reactivity: Human
- Application: ELISA, IP, WB
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: WB, ELISA, FC, ICC, IHC
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, ELISA
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For Research Use Only. Not For Clinical Use.