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KLRB1
Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein is classified as a type II membrane protein because it has an external C terminus.
Protein class
CD markers
Predicted location
Membrane
Single cell type specificity
Group enriched (NK-cells, T-cells, dendritic cells)
Immune cell specificity
Immune cell enhanced (MAIT T-cell)
Cell line specificity
Not detected
Interaction
Homodimer; disulfide-linked. Interacts with acid sphingomyelinase/SMPD1.
Molecular function
Receptor
More Types Infomation
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, FC
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- Species Reactivity: Human
- Application: FC, IHC-Fr, IP
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: FC, IHC, IP
- Mouse Anti-KLRB1 Recombinant Antibody (clone PK136) (VS3-WK1524)
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- Derivation: Mouse
- Species Reactivity: Mouse
- Type: Mouse IgG2a, κ
- Application: IF, FC
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For Research Use Only. Not For Clinical Use.