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LOX
This gene encodes a member of the lysyl oxidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a regulatory propeptide and the mature enzyme.
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Fibroblasts, Basal respiratory cells, Extravillous trophoblasts, Early spermatids, Peritubular cells, Club cells, Endometrial stromal cells, Smooth muscle cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (BJ, fHDF/TERT166, HSkMC, U-138 MG)
Interaction
Interacts with MFAP4 (PubMed:26601954). Interacts (via propeptide) with EFEMP2; this interaction is strong and facilitates formation of ternary complexes with ELN during elastic fiber assembly; this interaction limits interaction of EFEMP2 with FBLN5 (PubMed:19855011).
Molecular function
Oxidoreductase
More Types Infomation
- Recombinant Human Anti-human LOX Antibody Fab Fragment (MHH-629-F(E))
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- Derivation: Human
- Species Reactivity: Human
- Type: Fab
- Application: ELISA, FuncS
-
- Species Reactivity: Human, Mouse, Rat, Zebrafish
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
- Recombinant Human Anti-human LOX Antibody scFv Fragment (MHH-629-S(P))
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- Derivation: Human
- Species Reactivity: Human
- Type: scFv
- Application: ELISA, WB, FuncS
-
- Derivation: Human
- Species Reactivity: Human
- Type: IgG
- Application: FC, RIA, Biosensors, FuncS
- Recombinant Anti-human LOX Antibody scFv Fragment (MOB-629-S(P))
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: FC, Neut, Funcs
- Recombinant Anti-human LOX Antibody Fab Fragment (MOB-629-F(E))
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: IF, FC, FuncS
- Recombinant Anti-human LOX Antibody (MOB-629)
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: IgG
- Application: ELISA, WB, IF, FuncS
- Mouse Anti-LOX Recombinant Antibody (clone 2G5) (VS3-XY1016)
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IP, IF, IHC
-
- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: WB
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For Research Use Only. Not For Clinical Use.