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LTBP1
The protein encoded by this gene belongs to the family of latent TGF-beta binding proteins (LTBPs). The secretion and activation of TGF-betas is regulated by their association with latency-associated proteins and with latent TGF-beta binding proteins. The product of this gene targets latent complexes of transforming growth factor beta to the extracellular matrix, where the latent cytokine is subsequently activated by several different mechanisms. Alternatively spliced transcript variants encoding different isoforms have been identified.
Protein class
Plasma proteins
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Peritubular cells, Fibroblasts, Astrocytes, Leydig cells, Skeletal myocytes)
Immune cell specificity
Immune cell enriched (basophil)
Cell line specificity
Cell line enhanced (ASC TERT1, HSkMC, HUVEC TERT2, U-2197, U-87 MG)
Interaction
Interacts with TGFB1; associates via disulfide bonds with the Latency-associated peptide chain (LAP) regulatory chain of TGFB1, leading to regulate activation of TGF-beta-1 (PubMed:10930463, 2022183, 8617200, 15567420, 8939931, 22278742). LTBP1 does not bind directly to TGF-beta-1, the active chain of TGFB1 (PubMed:10930463). Interacts (via C-terminal domain) with FBN1 (via N-terminal domain) (PubMed:12429738, 17293099, 33991472). Interacts with FBN2 (PubMed:12429738, 33991472). Interacts with ADAMTSL2 (PubMed:18677313). Interacts with EFEMP2 (PubMed:27339457).
Molecular function
Growth factor binding
More Types Infomation
Related Signaling Pathways
TGF-β Signaling Pathway
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: WB
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IHC
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For Research Use Only. Not For Clinical Use.