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MAFA
Acts as a transcriptional factor. Specifically binds the insulin enhancer element RIPE3b and activates insulin gene expression. Cooperates synergistically with NEUROD1 and PDX1. Phosphorylation by GSK3 increases its transcriptional activity and is required for its oncogenic activity. Involved either as an oncogene or as a tumor suppressor, depending on the cell context.
Protein class
Disease related genes, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Group enriched (Enteroendocrine cells, Skeletal myocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (HaCaT, MCF7, RH-30, SCLC-21H, T-47d, U-2 OS)
Interaction
Forms homodimers or heterodimers (PubMed:12011435, PubMed:23148532). Monomers and dimers are able to bind DNA, but the off-rate is faster for monomers (PubMed:23148532). Interacts with NEUROD1 and PDX1 (By similarity). May interact with MAFB, FOS, JUN and PCAF (By similarity).
Molecular function
Activator, DNA-binding
More Types Infomation
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- Species Reactivity: Human
- Application: WB
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgM, κ
- Application: WB, IP, IF, ELISA
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For Research Use Only. Not For Clinical Use.