Loading...
MAP2
Microtubule-associated protein 2 (MAP2) is a neuronal phosphoprotein that regulates the structure and stability of microtubules, neuronal morphogenesis, cytoskeleton dynamics and organelle trafficking in axons and dendrites. Phosphorylation of MAP2 modulates its association with the cytoskeleton and is developmentally regulated. Serine 136, threonine 1620 and threonine 1623 of MAP2 are phosphorylated by GSK3 and p44/42 MAP kinases. Phosphorylation at threonine 1620/1623 by GSK3 inhibits MAP2 association with microtubules and microtubule stability.
Protein class
FDA approved drug targets, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Group enriched (Excitatory neurons, Cone photoreceptor cells, Inhibitory neurons, Oligodendrocyte precursor cells, Rod photoreceptor cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (AF22, NTERA-2, SCLC-21H, SH-SY5Y)
Interaction
Interacts with KNDC1 (via KIND2); the interaction enhances MAP2 phosphorylation and localizes KNDC1 to dendrites. Interacts with DPYSL5 (PubMed:33894126).
Molecular function
Calmodulin-binding
More Types Infomation
- Mouse Anti-MAP2 Recombinant Antibody (clone 7D4) (MOB-0095F)
-
- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG
- Application: IHC-P, IF
-
- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: IHC-P, IP, WB
- Rabbit Anti-MAP2 Recombinant Antibody (clone AFY0068) (MOR-0097-FY)
-
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: ICC, IHC-P, WB
-
- Species Reactivity: Rat
- Application: IHC-P, WB
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, ELISA, ICC, IHC, IP
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, ELISA
-
- Species Reactivity: Human, Bovine, Mouse, Rat, Porcine
- Type: Mouse IgG2b
- Application: ELISA, WB, ICC
-
- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG
- Application: ELISA, IHC
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA
- Chicken Anti-MAP2 Polyclonal IgY (BRD-0797MZ)
-
- Species Reactivity: Chicken, Horse, Human, Mouse, Pig, Rat, Bovine
- Type: Chicken antibody
- Application: ICC, IF, IHC, WB
- Mouse Anti-MAP2 Recombinant Antibody (clone 5B7) (VS3-XY1024)
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, FC
-
- Species Reactivity: Bovine
- Type: Chicken antibody
- Application: ICC
-
- Derivation: Mouse
- Species Reactivity: Human, Mouse
- Type: Mouse IgG2b
- Application: WB, IP, ICC
-
- Species Reactivity: Human, Mouse
- Type: Mouse IgG
- Application: WB, ICC
-
- Species Reactivity: Human, Mouse, Rat, Bovine, Pig
- Type: Mouse IgG
- Application: WB, IF
-
- Species Reactivity: Human, Mouse, Rat, Bovine, Dog
- Type: Mouse IgG
- Application: WB
Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us
Can't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag
For Research Use Only. Not For Clinical Use.