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NCOA1
The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Protein class
Cancer-related genes, Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Astrocytes, Oligodendrocyte precursor cells, Inhibitory neurons, Microglial cells, Excitatory neurons, Oligodendrocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (RH-30)
Interaction
Interacts with the methyltransferase CARM1 (By similarity). Interacts with NCOA6 and NCOA2. Interacts with the FDL motif of STAT5A and STAT5B. Interacts with the LXXLL motif of STAT6. Interacts with STAT3 following IL-6 stimulation. Interacts with the basal transcription factor GTF2B. Interacts with the histone acetyltransferases EP300 and CREBBP. Interacts with PCAF, COPS5, NR3C1 and TTLL5/STAMP. Interacts with PSMB9. Interacts with UBE2L3; they functionally interact to regulate progesterone receptor transcriptional activity. Interacts with PRMT2 and DDX5. Interacts with ASXL1. Interacts with PRMT6. Interacts (via LXXLL 1, 2 and 3 motifs) with RORC (via AF-2 motif). Interacts in a ligand-dependent fashion with RXRA. Interacts with TRIP4. Interacts with NR4A3 (By similarity). Interacts with VDR.
Molecular function
Activator, Acyltransferase, Transferase
More Types Infomation
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: IHC, IP, WB
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC, IP
-
- Species Reactivity: Human
- Application: Dot, WB
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC-P, IP
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, ELISA
-
- Derivation: Rabbit
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, ELISA
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For Research Use Only. Not For Clinical Use.