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NEDD9
The protein encoded by this gene is a member of the CRK-associated substrates family. Members of this family are adhesion docking molecules that mediate protein-protein interactions for signal transduction pathways. This protein is a focal adhesion protein that acts as a scaffold to regulate signaling complexes important in cell attachment, migration and invasion as well as apoptosis and the cell cycle. This protein has also been reported to have a role in cancer metastasis.
Protein class
Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Alveolar cells type 1, Glandular and luminal cells, Adipocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (EFO-21, HSkMC)
Interaction
Homodimer. Can heterodimerize with HLH proteins ID2, E12, E47 and also with p130cas. Forms complexes in vivo with related adhesion focal tyrosine kinase (RAFTK), adapter protein CRKL and LYN kinase. Interacts with MICAL and TXNL4/DIM1. Interacts with BCAR3 (via Ras-GEF domain) (By similarity). Interacts with SH2D3C isoform 1 and isoform 2 (By similarity).
More Types Infomation
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- Species Reactivity: Human
- Application: ICC/IF, IP
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2b, κ
- Application: WB, ELISA, ICC, IF, IP
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- Species Reactivity: Human
- Type: Mouse IgG2b, κ
- Application: IF, IP
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- Species Reactivity: Mouse, Rat, Human
- Type: Mouse IgG1, κ
- Application: IF, IHC-P, WB, IP
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For Research Use Only. Not For Clinical Use.