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NSF
Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Interaction with AMPAR subunit GRIA2 leads to influence GRIA2 membrane cycling (By similarity).
Protein class
Enzymes, Transporters
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Inhibitory neurons, Excitatory neurons)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Homohexamer. Interacts with GABARAP and GABARAPL2. Interacts with GRIA2. Interacts with PLK2, leading to disrupt the interaction with GRIA2. Interacts with MUSK; may regulate MUSK endocytosis and activity (By similarity). Interacts with CDK16 (By similarity).
Molecular function
Hydrolase
More Types Infomation
- Mouse Anti-NSF Recombinant Antibody (clone 20D4) (MOB-3420z)
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a, κ
- Application: WB, IP, IF, ELISA
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For Research Use Only. Not For Clinical Use.