pan Cytokeratin

Pan Cytokeratin is an important tumor marker of epithelial origin, which has been studied in multiple epithelial-derived malignancies. It is widely existed in epithelial cells and is highly conserved. When the epithelium becomes cancerous or even cancerous, it continues to exist in epithelial tumors and can be transferred with the metastasis of cancer cells, still expressing CK type n5, which is basically the same as normal tissues. The normal lymph nodes have no epithelial components. If there is a squamous cell carcinoma metastasis in the lymph nodes, the keratin can be expressed and displayed in the lymph nodes to determine whether there is metastasis. Although CK staining of macrophages, reticulocytes and plasma cells were also positive, these mesenchymal cells could be identified by comparing the intensity of CK staining, the size of cells and nuclei, the morphology of nuclear chromatin and the distribution of cells in lymph nodes. Therefore, false positives could be excluded.