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PARK7
The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
Protein class
Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Homodimer (PubMed:12851414, PubMed:12796482, PubMed:12855764, PubMed:31653696). Binds EFCAB6/DJBP and PIAS2 (PubMed:11477070, PubMed:12851414, PubMed:12612053). Part of a ternary complex containing PARK7, EFCAB6/DJBP and AR (PubMed:12612053). Interacts (via N-terminus) with OTUD7B (PubMed:21097510). Interacts with BBS1, HIPK1, CLCF1 and MTERF (PubMed:16390825, PubMed:21097510). Forms a complex with PINK1 and PRKN (PubMed:19229105). Interacts (via C-terminus) with NCF1; the interaction is enhanced by LPS and modulates NCF1 phosphorylation and membrane translocation (By similarity). Interacts with NENF (PubMed:31536960).
Molecular function
Chaperone, Hydrolase, Protease, RNA-binding
More Types Infomation
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC, IP, FC
-
- Species Reactivity: Human
- Application: ICC/IF, IHC-FoFr, IHC-Fr, WB
-
- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, IHC-P, ICC, FC
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2b, κ
- Application: WB, ELISA, FC, ICC, IF
-
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC-Fr, IHC-P, ICC, IF, IP
- Recombinant Mouse Anti-PARK7 Antibody (clone 2B1G12) (VS3-FY1094)
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- Type: Mouse IgG1
- Application: ELISA, WB, IHC, FC
- Recombinant Mouse Anti-PARK7 Antibody (clone 2B1D7) (VS3-FY1093)
-
- Type: Mouse IgG1
- Application: ELISA, WB, IHC, FC
- Recombinant Mouse Anti-PARK7 Antibody (3E8) (EPAF-1014LC)
-
- Species Reactivity: Human
- Application: WB
- Rabbit Anti-PARK7 Recombinant Antibody (VS3-WK1113) (VS3-WK1113)
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- Derivation: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, ICC, IF, IHC, IP, FC
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For Research Use Only. Not For Clinical Use.