Plasma proteins
Membrane
Cell type enhanced (Muller glia cells, Excitatory neurons, Inhibitory neurons, Bipolar cells)
Not detected in immune cells
Cell line enriched (AF22)
The N-terminal extracellular domain forms homophilic interactions; these interactions activate p38 MAPK via TAOK2 and trigger endocytosis. Interacts with CDH2; this interaction may lead to CDH2 cointernalization. Interacts with CDH11. Interacts with TAOK2.
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For Research Use Only. Not For Clinical Use.