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PHB
This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3' UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Protein class
Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Proximal tubular cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (CACO-2)
Interaction
The mitochondrial prohibitin complex consists of two subunits (PHB1 and PHB2), assembled into a membrane-associated ring-shaped supercomplex of approximately 1 mDa (PubMed:11302691, 20959514, 28017329, 31522117). Interacts with STOML2 (PubMed:21746876). Interacts with MAP1LC3B (membrane-bound form LC3-II); the interaction requires PHB2 and takes place upon Parkin-mediated mitochondrial damage (PubMed:28017329). Interacts with STAT3 (unphosphorylated or phosphorylated at 'Ser-727') (PubMed:31899195). Interacts with CLPB (PubMed:31522117). Interacts with CD86 (via cytoplasmic domain); the interactions increases after priming with CD40 (By similarity). (Microbial infection) Interacts with SARS coronavirus/SARS-CoV nsp2 protein. (Microbial infection) Interacts with chikungunya virus spike glycoprotein E2. (Microbial infection) Interaction with human immunodeficiency virus type 1/HIV-1 envelope glycoprotein GP160. (Microbial infection) Interacts with human enterovirus 71/EV-71 capsid protein VP0, protein 3CD and protease 3C.
More Types Infomation
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- Species Reactivity: Human, Mouse, Rat, Zebrafish
- Type: Rabbit IgG
- Application: WB, IF, IHC, IP, FC
- Recombinant Anti-PHB Antibody scFv Fragment (MOB-767-S(P))
-
- Derivation: Mouse
- Type: scFv
- Application: WB, IHC, FuncS
- Recombinant Anti-PHB Antibody Fab Fragment (MOB-767-F(E))
-
- Derivation: Mouse
- Type: Fab
- Application: FC, Neut, Funcs
- Recombinant Human Anti-Polyhydroxybutyrate Antibody scFv Fragment (PABX-156-S (P))
-
- Derivation: Human
- Type: scFv
- Application: WB, ELISA, IF, FuncS
- Human Anti-PHB Antibody, mRNA (PABX-156-mRNA)
-
- Species Reactivity: Human
-
- Derivation: Human
- Type: IgG
- Application: WB, ELISA, IF, FuncS
- Rabbit Anti-PHB Polyclonal Antibody (MRO-2134-CN) (MRO-2134-CN)
-
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
-
- Species Reactivity: Human
- Application: ICC/IF, IHC-P, WB
- Recombinant Human Anti-PHB Antibody Fab Fragment (MHH-767-F(E))
-
- Derivation: Human
- Type: Fab
- Application: WB, IF, FuncS
- Recombinant Human Anti-PHB Antibody (MHH-767)
-
- Derivation: Human
- Type: IgG
- Application: IF, FC, FuncS
- Recombinant Human Anti-PHB Antibody scFv Fragment (MHH-767-S(P))
-
- Derivation: Human
- Type: scFv
- Application: IF, FC, Biosensors, FuncS
-
- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, IP, IHC-P, ICC, FC
- Recombinant Human Anti-Polyhydroxybutyrate Antibody Fab Fragment (PABX-156-F (E))
-
- Derivation: Human
- Type: Fab
- Application: WB, ELISA, IF, FuncS
- Recombinant Anti-PHB Antibody (MOB-767)
-
- Derivation: Mouse
- Type: IgG
- Application: ELISA, WB, Neut, FuncS
- Rabbit Anti-PHB Recombinant Antibody (VS3-CJ898) (VS3-CJ898)
-
- Species Reactivity: Human, Mouse, Rat, Zebrafish
- Type: Rabbit IgG
- Application: WB, ICC, IHC, IP, FC
- Mouse Anti-PHB Recombinant Antibody (VS3-CJ897) (VS3-CJ897)
-
- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG2b, κ
- Application: WB, IHC-P
-
- Derivation: Mouse
- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG2b, κ
- Application: WB, IHC
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For Research Use Only. Not For Clinical Use.