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PLAG1
Pleomorphic adenoma gene 1 encodes a zinc finger protein with 2 putative nuclear localization signals. PLAG1, which is developmentally regulated, has been shown to be consistently rearranged in pleomorphic adenomas of the salivary glands. PLAG1 is activated by the reciprocal chromosomal translocations involving 8q12 in a subset of salivary gland pleomorphic adenomas. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Protein class
Cancer-related genes, Disease related genes, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Horizontal cells, Microglial cells, Rod photoreceptor cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (ASC diff, ASC TERT1, hTERT-HME1)
Interaction
Interacts with KPNA2, which escorts protein to the nucleus via interaction with nuclear localization signal. Interacts with E3 SUMO-protein ligase PIAS1, PIAS2 and PIAS4.
Molecular function
Activator, DNA-binding
More Types Infomation
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- Species Reactivity: Human
- Application: WB
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For Research Use Only. Not For Clinical Use.