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PLN
The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy.
Protein class
Disease related genes, Human disease related genes, Potential drug targets, Transporters
Predicted location
Membrane
Single cell type specificity
Cell type enriched (Cardiomyocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Not detected
Interaction
Homopentamer (PubMed:16043693, 16897780). Interacts with HAX1 (PubMed:17241641). Interact with ATP2A2; the inhibition decreases ATP2A2 Ca(2+) affinity (PubMed:28890335). Interacts with VMP1; VMP1 competes with PLN and SLN to prevent them from forming an inhibitory complex with ATP2A2 (PubMed:28890335). Interacts with S100A1 in a Ca(2+)-dependent manner (PubMed:12804600).
More Types Infomation
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: IHC-P, WB
- Recombinant Mouse Anti-PLN Antibody (2D12) (NEUT-1868CQ)
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- Species Reactivity: Human, Mouse, Chicken, Dog, Pig, Rat, Guinea pig, Rabbit, Sheep, Rodent
- Type: IgG2a
- Application: BL, ICC/IF, IHC-P, IP, WB
- Mouse Anti-PLN Recombinant Antibody (clone 39B8) (MOB-3504z)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, IP, IF, IHC, ELISA
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- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB
- Recombinant Rabbit Anti-PLN Antibody (clone R03-1I2) (VS3-FY1153)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC-P, IP
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For Research Use Only. Not For Clinical Use.