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PPIB
The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta.
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Plasma cells, Extravillous trophoblasts)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Interacts with DYM. Interacts with CALR, CLGN and CANX. Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGGT1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX (PubMed:12475965). (Microbial infection) Interacts with measles virus nucleoprotein.
Molecular function
Isomerase, Rotamase
More Types Infomation
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a, κ
- Application: WB, IP, IF, IHC, ELISA
-
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB
-
- Derivation: Phage display library screening
- Species Reactivity: Mouse, Rat, Human
- Type: IgG
- Application: WB
-
- Species Reactivity: Human, Rat, Mouse
- Type: Mouse IgG
- Application: IF/ICC, WB, IHC-P
-
- Species Reactivity: Human, Rat, Mouse
- Type: Mouse IgG
- Application: IF/ICC, WB, IHC-P
-
- Species Reactivity: Human, Rat, Mouse
- Type: Mouse IgG
- Application: IF/ICC, WB, IHC-P
-
- Species Reactivity: Human, Rat, Mouse
- Type: Mouse IgG
- Application: IF/ICC, WB, IHC-P
-
- Species Reactivity: Human, Rat, Mouse
- Type: Mouse IgG
- Application: IF/ICC, WB, IHC-P
-
- Species Reactivity: Human, Rat, Mouse
- Type: Mouse IgG
- Application: IF/ICC, WB, IHC-P
-
- Species Reactivity: Human, Rat, Mouse
- Type: Mouse IgG
- Application: IF/ICC, WB, IHC-P
-
- Species Reactivity: Human, Rat, Mouse
- Type: Mouse IgG
- Application: IF/ICC, WB, IHC-P
-
- Species Reactivity: Human, Rat, Mouse
- Type: Mouse IgG
- Application: IF/ICC, WB, IHC-P
-
- Species Reactivity: Human, Rat, Mouse
- Type: Mouse IgG
- Application: IF/ICC, WB, IHC-P
-
- Species Reactivity: Human, Rat, Mouse
- Type: Mouse IgG
- Application: IF/ICC, WB, IHC-P
-
- Species Reactivity: Human, Rat, Mouse
- Type: Mouse IgG
- Application: WB, IHC-P, IF
- Mouse Anti-PPIB Recombinant Antibody (VS3-WK1388) (VS3-WK1388)
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- Derivation: Mouse
- Species Reactivity: Human, Rat, Mouse
- Type: Mouse IgG
- Application: WB, IHC-P
-
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB
- Mouse Anti-PPIB Recombinant Antibody (VS3-CJ793) (VS3-CJ793)
-
- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG
- Application: WB, IHC
-
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB
-
- Derivation: Mouse
- Species Reactivity: Human, Rat, Mouse
- Type: Mouse IgG1
- Application: WB, IHC
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For Research Use Only. Not For Clinical Use.