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PRC1
This gene encodes a protein that is involved in cytokinesis. The protein is present at high levels during the S and G2/M phases of mitosis but its levels drop dramatically when the cell exits mitosis and enters the G1 phase. It is located in the nucleus during interphase, becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis. This protein has been shown to be a substrate of several cyclin-dependent kinases (CDKs). It is necessary for polarizing parallel microtubules and concentrating the factors responsible for contractile ring assembly. Alternative splicing results in multiple transcript variants.
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Erythroid cells, Spermatocytes, Spermatogonia, Extravillous trophoblasts)
Immune cell specificity
Immune cell enriched (basophil)
Cell line specificity
Low cell line specificity
Interaction
Homodimer (PubMed:20691902). Interacts with the C-terminal Rho-GAP domain and the basic region of RACGAP1 (PubMed:14744859). The interaction with RACGAP1 inhibits its GAP activity towards CDC42 in vitro, which may be required for maintaining normal spindle morphology (PubMed:14744859). Interacts (via N-terminus) with the C-terminus of CENPE (via C-terminus); the interaction occurs during late mitosis (PubMed:15297875). Interacts (via N-terminus) with KIF4A (via C-terminus); the interaction is required for the progression of mitosis (PubMed:15297875, 16431929, 29848660). Interacts (via N-terminus) with KIF23 (via C-terminus); the interaction occurs during late mitosis (PubMed:15297875). Interacts with KIF14 and KIF20A (PubMed:15625105, 16431929). Interacts with PLK1 (PubMed:19468300). Interacts with KIF20B (PubMed:17409436).
More Types Infomation
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: IHC-P, WB, IHC-P, ICC/IF, FC, IP
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- Species Reactivity: Saccharomyces cerevisiae
- Application: ICC/IF, WB
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For Research Use Only. Not For Clinical Use.