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PRG2
Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA.
Protein class
FDA approved drug targets, Plasma proteins
Predicted location
Secreted
Single cell type specificity
Group enriched (Extravillous trophoblasts, Erythroid cells)
Immune cell specificity
Immune cell enriched (basophil)
Cell line specificity
Group enriched (HL-60, HMC-1, NB-4)
Interaction
In pregnancy serum, the proform exists as a disulfide-linked 2:2 heterotetramer with PAPPA, as a disulfide-linked 2:2 heterotetramer with AGT, and as a complex (probably a 2:2:2 heterohexamer) with AGT and C3dg.
Molecular function
Antibiotic, Antimicrobial, Heparin-binding
More Types Infomation
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- Species Reactivity: Human
- Application: ELISA, IHC-Fr, IHC-P, WB
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IHC, ELISA
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For Research Use Only. Not For Clinical Use.