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PTGIR
The protein encoded by this gene is a member of the G-protein coupled receptor family 1 and has been shown to be a receptor for prostacyclin. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and inhibition of platelet aggregation through binding to this receptor. [provided by RefSeq, Jul 2008]
Protein class
FDA approved drug targets, G-protein coupled receptors
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Group enriched (Langerhans cells, monocytes)
Immune cell specificity
Group enriched (intermediate monocyte, non-classical monocyte, classical monocyte, myeloid DC)
Cell line specificity
Cell line enhanced (BJ, BJ hTERT+, fHDF/TERT166, HDLM-2, HEL, HHSteC)
Interaction
Interacts (non-isoprenylated C-terminus) with PDZK1.
Molecular function
G-protein coupled receptor, Receptor, Transducer
More Types Infomation
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- Species Reactivity: Human
- Application: ELISA, IHC-P, WB
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For Research Use Only. Not For Clinical Use.