PTP1B

Protein tyrosine phosphatase (PTP) is involved in the regulation of growth, proliferation, differentiation and metabolism of various cells. PTP1B is a classical non-receptor tyrosine in the protein tyrosine phosphatase family. PTP1B consists of 435 amino acids with a molecular weight of approximately 50 kD and is abundantly expressed in tissues such as liver, muscle and fat. Studies have shown that PTP1 B has an important reverse regulation in the insulin signaling pathway, which blocks insulin signaling by dephosphorylation of the insulin receptor and its substrate tyrosine. Therefore, PTP1B is considered to be an attractive drug target for the treatment of type 2 diabetes and metabolic syndrome, and PTP1B inhibitors are expected to be effective anti-diabetic/obesity treatment drugs.