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RAD51B
The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are evolutionarily conserved proteins essential for DNA repair by homologous recombination. This protein has been shown to form a stable heterodimer with the family member RAD51C, which further interacts with the other family members, such as RAD51, XRCC2, and XRCC3. Overexpression of this gene was found to cause cell cycle G1 delay and cell apoptosis, which suggested a role of this protein in sensing DNA damage. Rearrangements between this locus and high mobility group AT-hook 2 (HMGA2, GeneID 8091) have been observed in uterine leiomyomata.
Protein class
Cancer-related genes, Disease related genes
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Group enriched (Oligodendrocytes, Microglial cells, Oligodendrocyte precursor cells, Astrocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Part of the BCDX2 complex consisting of RAD51B, RAD51C, RAD51D and XRCC2; the complex has a ring-like structure arranged into a flat disc around a central channel (PubMed:11744692, PubMed:11751635, PubMed:11751636, PubMed:11842112, PubMed:11842113, PubMed:12427746, PubMed:14704354). The BCDX2 subcomplex RAD51B:RAD51C interacts with RAD51 (PubMed:11744692, PubMed:11751635, PubMed:11751636, PubMed:11842112, PubMed:11842113, PubMed:12427746, PubMed:14704354). Interacts with SWSAP1; involved in homologous recombination repair (PubMed:21965664). Interacts with HELQ (PubMed:24005041).
Molecular function
DNA-binding
More Types Infomation
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, ICC
- Mouse Anti-RAD51B Recombinant Antibody (clone 1h3/13) (FAMAB-1238CQ)
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- Species Reactivity: Primate, Human
- Type: Mouse IgG2a
- Application: IP, WB
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- Species Reactivity: Human
- Application: WB
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For Research Use Only. Not For Clinical Use.