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RCC1
RCC1 (Regulator Of Chromosome Condensation 1) is a Protein Coding gene. Diseases associated with RCC1 include Renal-Hepatic-Pancreatic Dysplasia and Retinitis Pigmentosa. Among its related pathways are Transport of the SLBP independent Mature mRNA and DNA Damage. Gene Ontology (GO) annotations related to this gene include chromatin binding and nucleosomal DNA binding. An important paralog of this gene is RPGR.
Protein class
Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enriched (Late spermatids)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Interacts with RAN (PubMed:17435751, PubMed:18762580, PubMed:29040603, PubMed:11336674). Interacts (via N-terminus and RCC1 repeats) with KPNA4 (PubMed:29042532). Interacts with ARRB2; the interaction is detected in the nucleus upon OR1D2 stimulation (PubMed:16820410).
Molecular function
DNA-binding, Guanine-nucleotide releasing factor
More Types Infomation
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: ICC, IHC-P, IP, WB
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- Species Reactivity: Human
- Application: IHC-P, WB
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, ELISA, ICC, IF, IHC
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IF, IP
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For Research Use Only. Not For Clinical Use.