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RCOR1
RCOR1 (REST Corepressor 1) is a Protein Coding gene. This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining neural cell differentiation. The encoded protein binds to the C-terminal domain of REST. Diseases associated with RCOR1 include Joubert Syndrome 1.
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Suprabasal keratinocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Interacts directly with GFI1 and GFI1B in a RCOR/GFI/KDM1A/HDAC complex. Interacts with INMS1 (By similarity). Component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST and PHF21A/BHC80. The BHC complex may also contain ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. Interacts with REST. Interacts with the SMARCE1/BAF57, suggesting that the BHC complex may recruit the ATP-dependent chromatin-remodeling SWI-SNF complex. (Microbial infection) Interacts with herpes virus HSV-1 ICP0 protein; the interaction leads to the disruption of the BHC complex, thereby preventing the BHC complex from repressing transcription of viral genes.
Molecular function
Chromatin regulator, Repressor
More Types Infomation
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- Species Reactivity: Human
- Application: WB, IHC-P
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, FC
- Rabbit Anti-RCOR1 Recombinant Antibody (clone rK72/8R) (VS-0422-LC55)
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- Species Reactivity: Rat, Human, Mouse
- Type: Rabbit IgG
- Application: WB, IHC
- Human Anti-RCOR1 Recombinant Antibody (clone hK72/8R) (VS-0422-LC54)
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- Species Reactivity: Rat, Human, Mouse
- Type: Human IgG1
- Application: WB, IHC
- Rat Anti-RCOR1 Recombinant Antibody (clone rtK72/8R) (VS-0422-LC53)
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- Species Reactivity: Rat, Human, Mouse
- Type: Rat IgG2b
- Application: WB, IHC
- Mouse Anti-RCOR1 Recombinant Antibody (clone mK72/8R) (VS-0422-LC52)
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- Species Reactivity: Rat, Human, Mouse
- Type: Mouse IgG2a
- Application: WB, IHC
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For Research Use Only. Not For Clinical Use.