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RRM2
This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Sep 2009]
Protein class
Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins
Predicted location
Membrane
Single cell type specificity
Group enriched (Extravillous trophoblasts, Plasma cells, Erythroid cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Heterodimer of a large and a small subunit. Interacts (via Cy motif and when phosphorylated at Thr-33) with CCNF; the interaction occurs exclusively in G2 and early M (PubMed:22632967).
Molecular function
Oxidoreductase
More Types Infomation
- Mouse Anti-RRM2 Antibody (clone SAIC-30C-18), mRNA (FAMAB-1250CQ-mRNA)
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- Species Reactivity: Human
- Mouse Anti-RRM2 Antibody (clone SAIC-30E-7), mRNA (FAMAB-1249CQ-mRNA)
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- Species Reactivity: Human
- Recombinant Mouse Anti-Human RRM2 Antibody (MOB-0823MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: ICC/IF, WB
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IP, IF
- Mouse Anti-RRM2 Recombinant Antibody (clone SAIC-30C-18) (FAMAB-1250CQ)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, Immuno-MRM, ELISA
- Mouse Anti-RRM2 Recombinant Antibody (clone SAIC-30E-7) (FAMAB-1249CQ)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: Immuno-MRM, ELISA
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, ICC/IF, IP
- Chicken Anti-RRM2 Polyclonal IgY (BRD-0517MZ)
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- Species Reactivity: Human
- Type: Chicken antibody
- Application: WB
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, ICC, IF, IP
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For Research Use Only. Not For Clinical Use.