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SH2D3C
This gene encodes an adaptor protein and member of a cytoplasmic protein family involved in cell migration. The encoded protein contains a putative Src homology 2 (SH2) domain and guanine nucleotide exchange factor-like domain which allows this signaling protein to form a complex with scaffolding protein Crk-associated substrate. Multiple transcript variants encoding different isoforms have been found for this gene.
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Adipocytes, Endothelial cells, Hepatic stellate cells, dendritic cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (HMC-1, HUVEC TERT2, REH, RPMI-8226, TIME)
Interaction
Component of a complex comprised of SH2D3C, BCAR1/CAS, and CRK (PubMed:12432078). Within the complex, interacts with CRK and (via C-terminus) with BCAR1/CAS (via C-terminus) (PubMed:12432078, PubMed:17174122, PubMed:22081014). Interacts with NEDD9/HEF1 (By similarity). Interacts with EPHB2 (By similarity). [Isoform 1]: Interacts with NEDD9/HEF1 (By similarity). Interacts with BCAR1/CAS (By similarity). Interacts with PTK2B (By similarity). [Isoform 2]: Interacts (via C-terminus) with BCAR1/CAS (via C-terminus) (By similarity). Interacts with IGF1 (PubMed:20881139).
More Types Infomation
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- Species Reactivity: Human
- Application: IHC-P, WB
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, ELISA, IHC
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- Derivation: Phage display library screening
- Species Reactivity: Mouse, Rat, Human
- Type: IgG
- Application: WB
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For Research Use Only. Not For Clinical Use.