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SLAMF1
SLAMF1 (Signaling Lymphocytic Activation Molecule Family Member 1) is a Protein Coding gene. Diseases associated with SLAMF1 include Measles and Subacute Sclerosing Panencephalitis. Among its related pathways are Dendritic Cells Developmental Lineage Pathway and T Cell Co-Signaling Pathway: Ligand-Receptor Interactions. Gene Ontology (GO) annotations related to this gene include antigen binding. An important paralog of this gene is LY9.
Protein class
CD markers
Predicted location
Membrane, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Plasma cells, T-cells, B-cells, monocytes, Melanocytes)
Immune cell specificity
Immune cell enhanced (MAIT T-cell)
Cell line specificity
Cell line enriched (HDLM-2)
Interaction
Interacts (via cytoplasmic domain) with SH2D1A and SH2D1B; SH2D1A mediates association with FYN; SH2D1A binds to phosphorylated and not phosphorylated ITSM 1 (PubMed:9774102, PubMed:11313386, PubMed:11806999, PubMed:12458214). Interacts (via cytoplasmic domain phosphorylated on tyrosine residues) with INPP5D and PTPN11; presence of SH2D1A facilitates binding to INPP5D (PubMed:11313386, PubMed:12458214). Interacts with MAP4K1 (PubMed:20231852). Interacts with PIK3C3, BECN1 and UVRAG; indicative for an association with PI3K complex II (PI3KC3-C2) (PubMed:20818396). (Microbial infection) Interacts with measles hemagglutinin protein.
Molecular function
Host cell receptor for virus entry, Receptor
More Types Infomation
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: FC, ICC, IP
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: ELISA, FC, ICC/IF, IHC-Fr, IP
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, IP
- Recombinant Rat Anti-Slamf1 Antibody (TC15-12F12.2) (NEUT-1972CQ)
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- Species Reactivity: Mouse
- Type: IgG2a, κ
- Application: FC, Costim, IP, BL
- Human Anti-SLAMF1 Recombinant Antibody (VS-0723-WK117) (VS-0723-WK117)
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- Derivation: Chimeric (rabbit/human)
- Species Reactivity: Human
- Type: Chimeric (rabbit/human) IgG1
- Application: FC
- Recombinant Rat Anti-SLAMF1 Antibody (9D1) (FN-176CQ)
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- Species Reactivity: Fish, Mouse
- Type: Rat IgG1
- Application: FC, FuncS, Neut, IHC, IF
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For Research Use Only. Not For Clinical Use.