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SLC30A8

The protein encoded by this gene is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles. This gene is expressed at a high level only in the pancreas, particularly in islets of Langerhans. The encoded protein colocalizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells. Allelic variants of this gene exist that confer susceptibility to diabetes mellitus, noninsulin-dependent (NIDDM). Several transcript variants encoding different isoforms have been found for this gene.
Protein class

Human disease related genes, Transporters

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (Late spermatids, Pancreatic endocrine cells, Spermatogonia, Early spermatids, Proximal tubular cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Group enriched (U-266/70, U-266/84)

Interaction

Homodimer.

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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