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SSTR2

Engineered Antibody
Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney.
Protein class

FDA approved drug targets, G-protein coupled receptors

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Bipolar cells, Smooth muscle cells, Enteroendocrine cells, Sertoli cells)

Immune cell specificity

Immune cell enhanced (basophil)

Cell line specificity

Cell line enriched (SCLC-21H)

Interaction

Homodimer and heterodimer with SSTR3 and SSTR5. Heterodimerization with SSTR3 inactivates SSTR3 receptor function. Heterodimerization with SSTR5 is enhanced by agonist stimulation of SSTR2 and increases SSTR2 cell growth inhibition activity. Following agonist stimulation, homodimers dissociate into monomers which is required for receptor internalization. Interacts with beta-arrestin; this interaction is necessary for receptor internalization and is destabilized by heterodimerization with SSTR5 which results in increased recycling of SSTR2 to the cell surface. Interacts (via C-terminus) with SHANK1 (via PDZ domain).

Molecular function

G-protein coupled receptor, Receptor, Transducer

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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