Anti-ER-a36 (clone SNGmBI)-mc-MMAF ADC (CAT#: ADC-238CL)
This ADC product is composed of an anti-ER-a36 antibody (clone SNGmBI) conjugated via mc linker to MMAF(Ab-mc-MMAF). It has demonstrated a response in treatment by a MOA (Mechanism of Action) as microtubule inhibitor.
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Specifications
- Antibody Overview
- Anti-ER-a36 Monoclonal Antibody SNGmBI (mlgG2b)
- Clone
- SNGmBI
- Antibody Isotype
- mlgG2b
- Linker
- Mc (maleimidocaproyl)
- Linker Class/Description
- Class: Noncleavable linkers
Description: Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.
- Drug
- MMAF (Monomethyl auristatin F)
- Drug Class/Description
- Class: Auristatin
Description: Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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