Products

Anti-αvβ integrin receptor Immunocytokine, IgG (DI-17E6)-IL2 (ACFP-SH136)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-αvβ integrin receptor IgG to IL2. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the αvβ integrin receptor as well as the biological activity of IL2. DI-17E6 can enhance the activity of cytotoxic drug based therapies, leading to more anti-tumor activity in vivo. DI-17E6 causes the depolymerization of focal adhesions dependent on αvβ3 and αvB5. These signalling complexes assemble after integrin ligation. They organize communication with growth, survival and motility pathways, and their destruction can trigger apoptosis. Thus DI-17E6 uses a combination of mechanochemical and biochemical effects to affect endothelia and to increase stress on tumor cells. This immunocytokine was designed for treating tumor.      

Specifications
Target
αvβ integrin receptor
Molecule Class
L Kappa; IgG2-IL2
Species Reactivity
Human
Host
Humanized from Mouse
Expression Host
CHO
Clone
DI-17E6
Related Disease
Tumor
Cytokines 1
IL2
Cytokines 1 Description
Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.
Cytokine 1 Species
Human
Applications
This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
Alternative Names
CD51; MSK8; VNRA; VTNR
Entrez Gene ID
3685
UniProt ID
P06756

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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