This ia an antibody that competes for binding to human BDNF, and it can be used in treating pain, such as chronic pain, neuropathic pain and symptoms, conditions and diseases associated with such pain.
Figure 1 Cell based ERK phosphorylation assay in U20S TrkB/p75NTR cells.
The humanised anti-BDNF molecule, B30 demonstrated greater BDNF binding compared to R3BH1 and TrkB-Fc, as measured by inhibition of pERK activity in U20S TrkBp75NTR cells.
Figure2 Improved BDNF binding of humanised B30 clone in cell based TrkB phosphorylation assay in U20S TrkB/p75NTR cells.
B30 clone inhibits BDNF mediated TrkB receptor phosphorylation in TrkBp75NTR U20S cells.
Figure 4 In vivo electrophysiological recordings of spinal dorsal horn neurones in rats sustaining peripheral nerve injury.
Mechanical punctate (von Frey) responses were dose dependency attenuated by the anti-BDNF molecule, B30 (0.1 and 1 mgkg) and pregabalin.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-107 | Recombinant Anti-human BDNF Antibody | ELISA, WB, Dot, FuncS | IgG |
MHH-107 | Recombinant Human Anti-human BDNF Antibody | ELISA, WB, FuncS | IgG |
MRO-0166-CN | Rabbit Anti-BDNF Recombinant Antibody (clone CBACN-065) | WB, IHC, IF | Rabbit IgG |
VS3-CJ800 | Mouse Anti-BDNF Recombinant Antibody (VS3-CJ800) | WB | Mouse IgG |
VS3-CJ801 | Rabbit Anti-BDNF Recombinant Antibody (VS3-CJ801) | WB, ICC, IF, IHC | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-107-F(E) | Recombinant Anti-human BDNF Antibody Fab Fragment | ELISA, IP, FuncS | Fab |
MHH-107-F(E) | Recombinant Human Anti-human BDNF Antibody Fab Fragment | ELISA, WB, Neut, FuncS | Fab |
HPAB-0351-FY-F(E) | Human Anti-BDNF Recombinant Antibody (clone R3BH1); Fab Fragment | Block | Chimeric (chicken/human) Fab, λ |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-107-S(P) | Recombinant Anti-human BDNF Antibody scFv Fragment | FC, RIA, Biosensors, FuncS | scFv |
MHH-107-S(P) | Recombinant Human Anti-human BDNF Antibody scFv Fragment | ELISA, WB, IF, FuncS | scFv |
HPAB-0351-FY-S(P) | Chicken Anti-BDNF Recombinant Antibody (clone R3BH1); scFv Fragment | Block | Chicken scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-1247CL | Anti-Human BDNF Recombinant Antibody (B30) | Inhib, FuncS | Humanized antibody |
TAB-1249CL | Anti-Human BDNF Recombinant Antibody (B18) | FuncS | Humanized antibody |
TAB-1247CL-S(P) | Anti-Human BDNF Recombinant Antibody scFv Fragment (B30) | Inhib, FuncS | Humanized antibody |
TAB-1248CL-S(P) | Anti-Human BDNF Recombinant Antibody scFv Fragment (B20) | ELISA, Inhib | Humanized antibody |
TAB-1249CL-S(P) | Anti-Human BDNF Recombinant Antibody scFv Fragment (B18) | ELISA, Inhib | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
BRD-0825MZ | Chicken Anti-BDNF Polyclonal IgY | ELISA | Chicken antibody |
BRD-1149MZ | Chicken Anti-Human BDNF Polyclonal IgY | ELISA | Chicken antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-044CQ | Mouse Anti-BDNF Recombinant Antibody (clone CBL263) | ELISA, WB, Neut | Mouse IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-0351 | Hi-Affi™ Rabbit Anti-BDNF Recombinant Antibody (clone DS351AB) | WB, IHC | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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