Recombinant monoclonal antibody to BMPR1B. 11F2 is a type IgG antibody that can be potentially used for the treatment of bone diseases and cancers mediated by BMP expression/activity and/or associated with abnormal expression/activity of a receptor.
Figure 1 Anti-BMP2/4 monoclonal antibodies blocking BMP4 binding to type-II BMP receptors by Biacore analysis.
Figure 2 Anti-BMP2/4 monoclonal antibodies blocking BMP4 binding to type-1 BMP receptors by Biacore analysis.
Figure 3 Inhibition of BMP2 and BMP4 signaling by anti-BMP2/4 antibodies.
C2C12 cells were incubated with recombinant human BMP2 and varying concentrations of five different neutralizing anti-BMP2/4 monoclonal antibodies or IgGl control mAb. Cells were fixed, lysed, and assayed for alkaline phosphatase activity.
Figure 4 Inhibition of BMP2 and BMP4 signaling by anti-BMP2/4 antibodies.
C2C12 cells were incubated with recombinant human BMP4 and varying concentrations of five different neutralizing anti-BMP2/4 monoclonal antibodies or IgGl control mAb. Cells were fixed, lysed, and assayed for alkaline phosphatase activity.
Figure 5 Densitometry scanning that bone formation is significantly reduced by the anti-BMP2 monoclonal antibodies.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
NS-010CN-F(E) | Human Anti-BMPR Recombinant Antibody (clone 11F2); Fab Fragment | ELISA, FC | Human Fab |
NS-010CN-S(P) | Human Anti-BMPR Recombinant Antibody (clone 11F2); scFv Fragment | ELISA, FC | Human scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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