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Anti-C12orf4 Intrabody [(D-Arg)9] (IAB-B051(A))

Recombinant anti-C12orf4 intrabody linked to (D-Arg)9 works within cells and specifically reacts with protein C12orf4, expressed in E. cili cells. It has been showed an inhibition of mast cell activation and a decrease in allergic mediator release.      

Specifications
Immunogen
human chromosome 12 open reading frame 4
Host
human
Type
scFv-(D-Arg)9
Cell Penetrating Peptide
(D-Arg)9
It has been proven that polyarginine peptides composed of nine arginine amino acids (Arg-9) are able to translocate across cells very efficiently. This raises the question if molecular dynamics simulations would show a similar pathway for this highly hydrophilic and charged peptide as predicted for the Tat peptide. The simplicity of Arg-9 over other CPPs also helps isolate the role of the Arg sidechain on the translocation without the effect of other sidechains. Therefore, in this work we study computationally the translocation of Arg-9 through a lipid bilayer and show that the translocation mechanism is the same as for the Tat peptide.
Species Reactivity
human
Applications
Used for immunoassay techniques such as: Immunofluorescence; Flow Cytometry; Western blot; Functional studies
Target
Alternative Names
C12ORF4; chromosome 12 open reading frame 4; uncharacterized protein C12orf4
Entrez Gene ID
57102
UniProt ID
Q9NQ89

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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