The 15C12 antibody was derived from a hybridoma clone inoculated into pristane-primed BALB/c mice. 15C12 exhibited neutralizing activities at high IgG concentrations, enhancing activities at intermediate concentrations, and no activity at low concentrations. The epitope of 15C12 includes E309 in EDIII of DENV-1.
Figure 1 Identification of the E protein epitope recognized by 7F4.
Competition against biotinylated 7F4. MAbs 7F4 (closed circles), 3H12 (open circles), and 15C12 (open squares) were used as the first antibody.
A Mouse Monoclonal Antibody against Dengue Virus Type 1 Mochizuki Strain Targeting Envelope Protein Domain II and Displaying Strongly Neutralizing but Not Enhancing Activity
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• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
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CAT | Product Name | Application | Type |
---|---|---|---|
MRO-1102LC | Human Anti-DENV1 E Recombinant Antibody (MRO-1102LC) | ELISA | Human IgG1 |
MRO-1103LC | Human Anti-DENV1 E Recombinant Antibody (MRO-1103LC) | ELISA | Human IgG1 |
MRO-1104LC | Human Anti-DENV1 E Recombinant Antibody (MRO-1104LC) | ELISA | Human IgG1 |
MRO-1105LC | Human Anti-DENV1 E Recombinant Antibody (MRO-1105LC) | ELISA | Human IgG1 |
MRO-1111LC | Human Anti-DENV1 E Recombinant Antibody (MRO-1111LC) | ELISA | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-1088LC-F(E) | Anti-DENV1 E Recombinant Antibody Fab Fragment (15C12) | ELISA | Mouse Antibody |
MRO-1089LC-F(E) | Anti-DENV1 E Recombinant Antibody Fab Fragment (9B1) | ELISA | Mouse Antibody |
MRO-1090LC-F(E) | Anti-DENV1 E Recombinant Antibody Fab Fragment (8F6) | ELISA | Mouse Antibody |
MRO-1091LC-F(E) | Anti-DENV1 E Recombinant Antibody Fab Fragment (3C9) | ELISA | Mouse Antibody |
MRO-1092LC-F(E) | Anti-DENV1 E Recombinant Antibody Fab Fragment (7F4) | ELISA | Mouse Antibody |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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