Recombinant Human Antibody (ABT-007) is capable of binding to EPOR, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-EPOR mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-EPOR mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition.
Figure 1 ABT007 stimulates in vitro erythropoiesis.
(A) ABT007 stimulates the proliferation of EPO-responsive F36E human erythroleukemic cells. Error bars represent standard deviation (SD) calculated from the average of duplicate counts. (B) ABT007 supports the formation of erythroid colonies from hematopoietic precursor cells. Error bars represent standard deviation (SD) calculated from the average of duplicate counts. Typical colonies, identified microscopically, are shown below for (C) the isotype control–, (D) EPO-, and (E) ABT007-treated cells. The colonies were red in color.
Liu, Z., Stoll, V. S., DeVries, P. J., Jakob, C. G., Xie, N., Simmer, R. L., ... & Reilly, E. B. (2007). A potent erythropoietin-mimicking human antibody interacts through a novel binding site. Blood, 110(7), 2408-2413.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
---|---|---|---|
PFBW-040 | Human Anti-EPOR Recombinant Antibody (clone ABT-007); Fab Fragment | WB, FuncS | Human Fab |
HPAB-0490-CN-F(E) | Mouse Anti-EPOR Recombinant Antibody (clone 21.3.1); Fab Fragment | ELISA, WB, ICC, IHC, IP | Mouse Fab |
HPAB-0491-CN-F(E) | Mouse Anti-EPOR Recombinant Antibody (clone 19.1.2); Fab Fragment | ELISA, WB, ICC, IHC, IP | Mouse Fab |
HPAB-1849-FY-S(P) | Human Anti-EPOR Recombinant Antibody (clone Ab12); Fab Fragment | Activ | Human Fab |
HPAB-1850-FY-S(P) | Human Anti-EPOR Recombinant Antibody (clone Ab198); Fab Fragment | Activ | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBW-040 | Human Anti-EPOR Recombinant Antibody (clone ABT-007); scFv Fragment | WB, FuncS | Human scFv |
HPAB-0490-CN-S(P) | Mouse Anti-EPOR Recombinant Antibody (clone 21.3.1); scFv Fragment | ELISA, WB, ICC, IHC, IP | Mouse scFv |
HPAB-0491-CN-S(P) | Mouse Anti-EPOR Recombinant Antibody (clone 19.1.2); scFv Fragment | ELISA, WB, ICC, IHC, IP | Mouse scFv |
HPAB-0359-YJ-S(P) | Human Anti-EPOR Recombinant Antibody; scFv Fragment (HPAB-0359-YJ-S(P)) | ELISA, FC, Activ, FuncS | Human scFv |
HPAB-0360-YJ-S(P) | Human Anti-EPOR Recombinant Antibody; scFv Fragment (HPAB-0360-YJ-S(P)) | ELISA, FC, Activ, FuncS | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-007WM | Anti-Human EPOR Recombinant Antibody (AB-ABT2-XG2-012) | ELISA | Human Antibody |
TAB-007WM-S(P) | Anti-Human EPOR Recombinant Antibody scFv Fragment (AB-ABT2-XG2-012) | ELISA | Human Antibody |
TAB-007WM-F(E) | Anti-Human EPOR Recombinant Antibody Fab Fragment (AB-ABT2-XG2-012) | ELISA | Human Antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-008WM | Anti-Human EPOR Recombinant Antibody (1E3) | ELISA, WB, FC | |
TAB-009WM | Mouse Anti-EPOR Recombinant Antibody (TAB-009WM) | WB, FC | Mouse IgG |
TAB-008WM-S(P) | Anti-Human EPOR Recombinant Antibody scFv Fragment (1E3) | ELISA, WB, FC | |
TAB-008WM-F(E) | Anti-Human EPOR Recombinant Antibody Fab Fragment (1E3) | ELISA, WB, FC | |
TAB-009WM-F(E) | Mouse Anti-EPOR Recombinant Antibody; Fab Fragment (TAB-009WM-F(E)) | WB, FC | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-0682CT | Recombinant Mouse anti-Human EPOR Monoclonal antibody (EML077) | WB | |
HPAB-0169CQ | Human Anti-EPOR Recombinant Antibody (clone ABT2-SCX-012) | Agonist, ELISA | Human IgG |
HPAB-0359-YJ | Human Anti-EPOR Recombinant Antibody (HPAB-0359-YJ) | ELISA, FC, Activ, FuncS | Human IgG2 |
HPAB-0360-YJ | Human Anti-EPOR Recombinant Antibody (HPAB-0360-YJ) | ELISA, FC, Activ, FuncS | Human IgG1 |
PABS-0017 | Human Anti-EpoR Diabody (Clone 330) | ELISA, FuncS | Human diabody |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-736CQ | Mouse Anti-EPOR Recombinant Antibody (clone CBL641) | Neut | Mouse IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-1173 | Hi-Affi™ Rabbit Anti-EPOR Recombinant Antibody (clone DS1173AB) | IP, WB | Rabbit IgG |
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