Products

Anti-EpCAM Immunocytokine, IgG (KS1/4)-IL2 (ACFP-SH068)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-EpCAM IgG to IL2. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the EpCAM as well as the biological activity of IL2. Normal IgG4 does not bind complement because it contains a serine instead of a corresponding proline at position 331 in IgG1 (Eu nomenclature). The fusion protein combined with a hinge region from the γ4 hinge with the serine to proline substitution. This immunocytokine was designed for treating solid tumor.      

Specifications
Target
EpCAM
Molecule Class
IgG4 (S to P)-IL2
Species Reactivity
Human
Host
Mouse
Expression Host
CHO
Clone
KS1/4
Related Disease
Melanoma
Cytokines 1
IL2
Cytokines 1 Description
Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.
Cytokine 1 Species
Human
Applications
This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
Alternative Names
EPCAM; epithelial cell adhesion molecule; ESA; KSA; M4S1; MK-1; DIAR5; EGP-2
Entrez Gene ID
4072
UniProt ID
P16422

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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