Recombinant Mouse Antibody (G99) is capable of binding to Coagulation factor VIII C2 domain, expressed in Chinese Hamster Ovary cells (CHO).
Figure 1 ELISA of C2-mAb interactions.
G99 IgG was incubated at various concentrations under the following conditions: ELISA wells coated with 3E6 Fab, blocked, and then coated with C2 (●); wells coated with 3E6 Fab and blocked (○); and wells blocked and then incubated with C2 domain only (■). Bound G99 IgG was detected using goat anti-mouse IgG-alkaline phosphatase.
Walter, J. D., Werther, R. A., Polozova, M. S., Pohlman, J., Healey, J. F., Meeks, S. L., ... & Spiegel, P. C. (2013). Characterization and solution structure of the factor VIII C2 domain in a ternary complex with classical and non-classical inhibitor antibodies. Journal of Biological Chemistry, 288(14), 9905-9914.
Figure 2 Bethesda assays for inhibition of fVIII activity in plasma.
Inhibition of fVIII activity by G99 whole IgG (○) and G99 Fab (●). 100% activity corresponds to the coagulation activity of pooled normal human plasma.
Walter, J. D., Werther, R. A., Polozova, M. S., Pohlman, J., Healey, J. F., Meeks, S. L., ... & Spiegel, P. C. (2013). Characterization and solution structure of the factor VIII C2 domain in a ternary complex with classical and non-classical inhibitor antibodies. Journal of Biological Chemistry, 288(14), 9905-9914.
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• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
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Gly-015LC | Recombinant Anti-Human F8 Antibody (Non-glycosylated) | ELISA | Human antibody |
CAT | Product Name | Application | Type |
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PABX-058 | Recombinant Human Anti-F8 Antibody (BO2C11) | WB, ELISA, FuncS, Inhib, PK, IP, SPR | IgG |
PABX-058-S (P) | Recombinant Human Anti-F8 Antibody scFv Fragment (BO2C11) | WB, ELISA, FuncS | scFv |
PABX-058-F (E) | Recombinant Human Anti-F8 Antibody Fab Fragment (BO2C11) | WB, ELISA, FuncS | Fab |
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NEUT-765CQ | Mouse Anti-F8 Recombinant Antibody (clone CBL215) | ELISA, WB, Neut | Mouse IgG2a |
CAT | Product Name | Application | Type |
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MOR-1229 | Hi-Affi™ Rabbit Anti-F8 Recombinant Antibody (clone DS1229AB) | ELISA | Rabbit IgG |
MOR-4166 | Hi-Affi™ Rabbit Anti-F8 Recombinant Antibody (clone SI243DS) | ELISA | Rabbit IgG |
MOR-4167 | Hi-Affi™ Rabbit Anti-F8 Recombinant Antibody (clone SI244DS) | ELISA | Rabbit IgG |
CAT | Product Name | Application | Type |
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EPAF-0611LC | Human Anti-F8 Recombinant Antibody (clone BO2C11) | ELISA | Human IgG4 |
CAT | Product Name | Application | Type |
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FAMAB-0197-CN | Human Anti-F8 Recombinant Antibody (clone KM33) | WB | Human IgG |
HPAB-1977-FY | Human Anti-F8 Recombinant Antibody (clone 92-137) | Inhib | Human IgG |
HPAB-1978-FY | Human Anti-F8 Recombinant Antibody (clone 92-102) | Inhib | Human IgG |
HPAB-1979-FY | Human Anti-F8 Recombinant Antibody (clone WR8) | IP | Human IgG4 |
HPAB-1980-FY | Human Anti-F8 Recombinant Antibody (clone WR11) | IP | Human IgG4 |
CAT | Product Name | Application | Type |
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FAMAB-0197-CN-F(E) | Human Anti-F8 Recombinant Antibody (clone KM33); Fab Fragment | WB | Human Fab |
HPAB-1977-FY-F(E) | Human Anti-F8 Recombinant Antibody (clone 92-137); Fab Fragment | Inhib | Human Fab |
HPAB-1978-FY-F(E) | Human Anti-F8 Recombinant Antibody (clone 92-102); Fab Fragment | Inhib | Human Fab |
HPAB-1979-FY-F(E) | Human Anti-F8 Recombinant Antibody (clone WR8); Fab Fragment | IP | Human Fab |
HPAB-1980-FY-F(E) | Human Anti-F8 Recombinant Antibody (clone WR11); Fab Fragment | IP | Human Fab |
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MHC-YF075 | DRB1*11:01/Factor VIII Factor VIII (ENIQRFLPNPAGVQLEDPEF) MHC Monomer | MHC Multimer |
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FAMAB-0038JF-S(P) | Human Anti-F8 Recombinant Antibody (clone DH10); scFv Fragment | IP, ELISA, FuncS | Human scFv |
FAMAB-0039JF-S(P) | Human Anti-F8 Recombinant Antibody (clone JM4); scFv Fragment | IP, ELISA, FuncS | Human scFv |
FAMAB-0200JF-S(P) | Human Anti-F8 Recombinant Antibody (clone KM41); scFv Fragment | WB, ELISA, FuncS | Human scFv |
FAMAB-0201JF-S(P) | Human Anti-F8 Recombinant Antibody (clone KM38); scFv Fragment | WB, ELISA, FuncS | Human scFv |
HPAB-1613WJ-S(P) | Human Anti-F8 Recombinant Antibody; scFv Fragment (clone KRIX 1) | ELISA, IP | Human scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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