Anti-Human FZD10 Recombinant Antibody (OTSA101) (CAT#: TAB-295CL)
Recombinant Chimeric monoclonal antibody expressed in CHO binding to Human FZD10. OTSA101 is an antibody drug targets a novel tumor-specific antigen FZD10 (Frizzled homolog 10), used for cancer therapy, has conducted phase I clinical trial for synovial sarcoma, which is a type of soft tissue sarcoma.
Specific Inquiry
RIA
Figure 1 Therapeutic results of radioimmunotherapy (RIT) with ²¹¹AtOTSA101 in the synovial sarcoma (SS) subcutaneous xenograft mouse model.
Changes in tumor volumes in the model mice after RIT with ²¹¹At-OTSA101. Plots were interrupted if the animal reached the defined endpoint. Five mice were enrolled in each of the treatment groups, except for the intact IgG control (4 mice).
Li, H. K., Sugyo, A., Tsuji, A. B., Morokoshi, Y., Minegishi, K., Nagatsu, K., ... & Nakamura, Y. (2018). α‐particle therapy for synovial sarcoma in the mouse using an astatine‐211‐labeled antibody against frizzled homolog 10. Cancer science, 109(7), 2302-2309.
IHC
Figure 2 Histopathological analyses of the synovial sarcoma (SS) xenografts by immunohistochemistry and H&E staining.
CD31 corresponding H&E staining at day 1 after ²¹¹At-OTSA101 treatment. Scale bars, 50 μm
Li, H. K., Sugyo, A., Tsuji, A. B., Morokoshi, Y., Minegishi, K., Nagatsu, K., ... & Nakamura, Y. (2018). α‐particle therapy for synovial sarcoma in the mouse using an astatine‐211‐labeled antibody against frizzled homolog 10. Cancer science, 109(7), 2302-2309.
Specifications
- Type
- Antibody
- Species Reactivity
- Human
- Applications
- RIA, IHC
- Related Disease
- Cancer
Product Property
- Purity
- >95%, by SDS-PAGE with Coomassie Brilliant Blue staining
- Storage
- Short Term Storage: 4°C
Long Term Storage: -20°C
Applications
- Application Notes
- This antibody has been reported for use in Radioimmunoassay and Immunohistochemistry.
Target
- Alternative Names
- FZD10; frizzled class receptor 10; Fz10; FzE7; CD350; FZ-10; hFz10; frizzled-10; frizzled homolog 10; frizzled family receptor 10; frizzled 10, seven transmembrane spanning receptor
- Gene ID
- 11211
- UniProt ID
- Q6NSL8
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "FZD10"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2133z | Mouse Anti-FZD10 Recombinant Antibody (MOB-2133z) | IHC, ELISA, IF, IP, FC | Mouse IgG |
| HPAB-0028LY | Mouse Anti-FZD10 Recombinant Antibody (HPAB-0028LY) | WB | Mouse IgG |
| VS-0723-WK82 | Human Anti-FZD10 Recombinant Antibody (VS-0723-WK82) | FC | Chimeric (rabbit/human) IgG1 |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2133z-F(E) | Recombinant Anti-Human FZD10 Antibody Fab Fragment | WB, IF, FuncS | Fab |
| HPAB-0028LY-F(E) | Mouse Anti-FZD10 Recombinant Antibody; Fab Fragment (HPAB-0028LY-F(E)) | WB | Mouse Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2133z-S(P) | Recombinant Anti-Human FZD10 Antibody scFv Fragment | RIA, ELISA, FuncS | scFv |
| HPAB-0028LY-S(P) | Mouse Anti-FZD10 Recombinant Antibody; scFv Fragment (HPAB-0028LY-S(P)) | WB | Mouse scFv |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-030CQ-S(P) | Human Anti-FZD10 Recombinant Antibody; scFv Fragment (TAB-030CQ-S(P)) | ELISA, FC, WB, Block | Humanized scFv |
| TAB-030CQ-F(E) | Human Anti-FZD10 Recombinant Antibody; Fab Fragment (TAB-030CQ-F(E)) | ELISA, FC, WB, Block | Humanized Fab |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-031CQ-S(P) | Mouse Anti-FZD10 Recombinant Antibody; scFv Fragment (TAB-031CQ-S(P)) | ELISA, FC, WB, Block | Mouse scFv |
| TAB-032CQ-S(P) | Mouse Anti-FZD10 Recombinant Antibody; scFv Fragment (TAB-032CQ-S(P)) | ELISA, FC, WB, Block | Mouse scFv |
| TAB-031CQ-F(E) | Human Anti-FZD10 Recombinant Antibody; Fab Fragment (TAB-031CQ-F(E)) | ELISA, FC, WB, Block | Chimeric (mouse/human) Fab |
| TAB-032CQ-F(E) | Human Anti-FZD10 Recombinant Antibody; Fab Fragment (TAB-032CQ-F(E)) | ELISA, FC, WB, Block | Chimeric (mouse/human) Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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